Methionine enkephalin in dog canine pulp

Meal-stimulated release of methionine-enkephalin into the canine jejunal lumen.

Application of enkephalins to the luminal surface of the bowel augments intestinal absorption. However, to date, endogenous enkephalins have not been demonstrated within intestinal luminal fluid. To determine whether enkephalins are present in the intestinal lumen, five adult dogs had 25-cm chronic jejunal Thiry-Vella loops constructed. Dogs were studied in the awake, fasted state. Jejunal loop...

Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.

To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with reverse-phase high-performance liquid chromato...

In vitro release of [5-methionine]enkephalin and [5-leucine]-enkephalin from the rat globus pallidus.

Endogenous [5-methionine]enkephalin (Metenkephalin) and [5-leucine]enkephalin (Leu-enkephalin) are released from perfused slices of rat globus pallidus by increased K(+) in a Ca(2+)-dependent manner. Tissue perfused for 40 min contained only 26% of the Met-enkephalin and 44% of the Leu-enkephalin found in the freshly dissected tissue. After perfusion, the mean (+/-SEM) ratio (wt/wt) of Met-enke...

Plasma methionine enkephalin concentration and prognosis in primary biliary cirrhosis.

The human spinal cord: substance P and methionine-enkephalin immunoreactivity.

The distribution of substance P-like (SPLI) and methionine-enkephalin-like (MELI) immunoreactivity in the thoracic, lumbar, and sacral human spinal cord was studied in sections stained by the indirect antibody peroxidase-antiperoxidase method. The laminar distributions of SPLI and MELI were somewhat similar. Immunoreactive axons and terminal-like processes were found in the marginal zone and su...